LymphedemaV1, Main, Exploration, bibRecord, 004A60

The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda

Identifieur interne : 004A60 ( Main/Exploration ); précédent : 004A59; suivant : 004A61

The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda

Auteurs : Ruth A. Ashton [Ouganda, Royaume-Uni] ; Daniel J. Kyabayinze [Ouganda] ; Tom Opio [Ouganda] ; Anna Auma [Ouganda] ; Tansy Edwards [Royaume-Uni] ; Gabriel Matwale [Ouganda] ; Ambrose Onapa [Ouganda] ; Simon Brooker [Royaume-Uni, Kenya] ; Jan H. Kolaczinski [Ouganda, Royaume-Uni]

Source :

Parasites & Vectors [ 1756-3305 ] ; 2011.

RBID : PMC:3158553

Descripteurs français

KwdFr :
- Adolescent, Albendazole (administration et posologie), Animaux, Anopheles (parasitologie), Antihelminthiques (administration et posologie), Enfant, Enfant d'âge préscolaire, Femelle, Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (transmission), Filariose lymphatique (épidémiologie), Humains, Insecticides (pharmacologie), Ivermectine (administration et posologie), Larve, Lutte contre les moustiques (), Moustiquaires de lit traitées aux insecticides, Mâle, Ouganda (épidémiologie), Wuchereria bancrofti (isolement et purification).
MESH :
- administration et posologie : Albendazole, Antihelminthiques, Ivermectine.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Anopheles.
- pharmacologie : Insecticides.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Ouganda.
- Adolescent, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Larve, Lutte contre les moustiques, Moustiquaires de lit traitées aux insecticides, Mâle.
Wicri :
- geographic : Ouganda.

English descriptors

KwdEn :
- Adolescent, Albendazole (administration & dosage), Animals, Anopheles (parasitology), Anthelmintics (administration & dosage), Child, Child, Preschool, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (transmission), Female, Humans, Insecticide-Treated Bednets, Insecticides (pharmacology), Ivermectin (administration & dosage), Larva, Male, Mosquito Control (methods), Uganda (epidemiology), Wuchereria bancrofti (isolation & purification).
MESH :
- chemical , administration & dosage : Albendazole, Anthelmintics, Ivermectin.
- geographic , epidemiology : Uganda.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- methods : Mosquito Control.
- parasitology : Anopheles.
- chemical , pharmacology : Insecticides.
- transmission : Elephantiasis, Filarial.
- Adolescent, Animals, Child, Child, Preschool, Female, Humans, Insecticide-Treated Bednets, Larva, Male.

Abstract

Background

Lymphatic filariasis (LF) in Uganda is caused by Wuchereria bancrofti and transmitted by anopheline mosquitoes. The mainstay of elimination has been annual mass drug administration (MDA) with ivermectin and albendazole, targeted to endemic districts, but has been sporadic and incomplete in coverage. Vector control could potentially contribute to reducing W. bancrofti transmission, speeding up progress towards elimination. To establish whether the use of long-lasting insecticidal nets (LLINs) can contribute towards reducing transmission of W. bancrofti in a setting with ongoing MDA, a study was conducted in an area of Uganda highly endemic for both LF and malaria. Baseline parasitological and entomological assessments were conducted in 2007, followed by high-coverage LLIN distribution. Net use and entomological surveys were carried out after one year, and final parasitological and entomological evaluations were conducted in 2010. Three rounds of MDA had taken place before the study commenced, with a further three rounds completed during the course of the study.

Results

In 2007, rapid mapping indicated 22.3% of schoolchildren were W. bancrofti antigen positive, and a baseline survey during the same year found age-adjusted microfilaraemia prevalence was 3.7% (95% confidence interval (CI): 2.6-5.3%). In 2010, age-adjusted microfilaraemia prevalence had fallen to 0.4%, while antigenaemia rates were 0.2% in children < 5 years and 6.0% in ≥ 5 years. In 2010, universal coverage of mosquito nets in a household was found to be protective against W. bancrofti antigen (odds ratio = 0.44, 95% CI: 0.22-0.89). Prevalence of W. bancrofti larvae in anopheline mosquitoes had decreased significantly between the 2007 and 2010 surveys, but there was an apparent increase in vector densities.

Conclusion

A marked reduction in W. bancrofti infection and infectivity in humans was observed in the study area, where both MDA and LLINs were used to reduce transmission. The extent to which LLINs contributed to this decline is equivocal, however. Further work investigating the impact of vector control on anopheline-transmitted LF in an endemic area not benefitting from MDA would be valuable to determine the effect of such interventions on their own.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158553

DOI: 10.1186/1756-3305-4-134
PubMed: 21756371
PubMed Central: 3158553

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Lymphatic filariasis (LF) in Uganda is caused by <italic>Wuchereria bancrofti </italic>
and transmitted by anopheline mosquitoes. The mainstay of elimination has been annual mass drug administration (MDA) with ivermectin and albendazole, targeted to endemic districts, but has been sporadic and incomplete in coverage. Vector control could potentially contribute to reducing <italic>W. bancrofti </italic>
transmission, speeding up progress towards elimination. To establish whether the use of long-lasting insecticidal nets (LLINs) can contribute towards reducing transmission of <italic>W. bancrofti </italic>
in a setting with ongoing MDA, a study was conducted in an area of Uganda highly endemic for both LF and malaria. Baseline parasitological and entomological assessments were conducted in 2007, followed by high-coverage LLIN distribution. Net use and entomological surveys were carried out after one year, and final parasitological and entomological evaluations were conducted in 2010. Three rounds of MDA had taken place before the study commenced, with a further three rounds completed during the course of the study.</p>
</sec>
<sec><title>Results</title>
<p>In 2007, rapid mapping indicated 22.3% of schoolchildren were <italic>W. bancrofti </italic>
antigen positive, and a baseline survey during the same year found age-adjusted microfilaraemia prevalence was 3.7% (95% confidence interval (CI): 2.6-5.3%). In 2010, age-adjusted microfilaraemia prevalence had fallen to 0.4%, while antigenaemia rates were 0.2% in children < 5 years and 6.0% in ≥ 5 years. In 2010, universal coverage of mosquito nets in a household was found to be protective against <italic>W. bancrofti </italic>
antigen (odds ratio = 0.44, 95% CI: 0.22-0.89). Prevalence of <italic>W. bancrofti </italic>
larvae in anopheline mosquitoes had decreased significantly between the 2007 and 2010 surveys, but there was an apparent increase in vector densities.</p>
</sec>
<sec><title>Conclusion</title>
<p>A marked reduction in <italic>W. bancrofti </italic>
infection and infectivity in humans was observed in the study area, where both MDA and LLINs were used to reduce transmission. The extent to which LLINs contributed to this decline is equivocal, however. Further work investigating the impact of vector control on anopheline-transmitted LF in an endemic area not benefitting from MDA would be valuable to determine the effect of such interventions on their own.</p>
</sec>
</div>
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<author><name sortKey="Malecela Lazaro, Mn" uniqKey="Malecela Lazaro M">MN Malecela-Lazaro</name>
</author>
<author><name sortKey="Michael, E" uniqKey="Michael E">E Michael</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Kenya</li>
<li>Ouganda</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="Ouganda"><noRegion><name sortKey="Ashton, Ruth A" sort="Ashton, Ruth A" uniqKey="Ashton R" first="Ruth A" last="Ashton">Ruth A. Ashton</name>
</noRegion>
<name sortKey="Auma, Anna" sort="Auma, Anna" uniqKey="Auma A" first="Anna" last="Auma">Anna Auma</name>
<name sortKey="Kolaczinski, Jan H" sort="Kolaczinski, Jan H" uniqKey="Kolaczinski J" first="Jan H" last="Kolaczinski">Jan H. Kolaczinski</name>
<name sortKey="Kyabayinze, Daniel J" sort="Kyabayinze, Daniel J" uniqKey="Kyabayinze D" first="Daniel J" last="Kyabayinze">Daniel J. Kyabayinze</name>
<name sortKey="Matwale, Gabriel" sort="Matwale, Gabriel" uniqKey="Matwale G" first="Gabriel" last="Matwale">Gabriel Matwale</name>
<name sortKey="Onapa, Ambrose" sort="Onapa, Ambrose" uniqKey="Onapa A" first="Ambrose" last="Onapa">Ambrose Onapa</name>
<name sortKey="Opio, Tom" sort="Opio, Tom" uniqKey="Opio T" first="Tom" last="Opio">Tom Opio</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ashton, Ruth A" sort="Ashton, Ruth A" uniqKey="Ashton R" first="Ruth A" last="Ashton">Ruth A. Ashton</name>
</region>
<name sortKey="Brooker, Simon" sort="Brooker, Simon" uniqKey="Brooker S" first="Simon" last="Brooker">Simon Brooker</name>
<name sortKey="Edwards, Tansy" sort="Edwards, Tansy" uniqKey="Edwards T" first="Tansy" last="Edwards">Tansy Edwards</name>
<name sortKey="Kolaczinski, Jan H" sort="Kolaczinski, Jan H" uniqKey="Kolaczinski J" first="Jan H" last="Kolaczinski">Jan H. Kolaczinski</name>
</country>
<country name="Kenya"><noRegion><name sortKey="Brooker, Simon" sort="Brooker, Simon" uniqKey="Brooker S" first="Simon" last="Brooker">Simon Brooker</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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   |texte=   The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda
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The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda

The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda

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